The Efficacy of Ginseng Extract
Pulished on Apr. 22, 2020
We all know that ginseng is a superior supplement, and its nutritional value is very high. It is very good to supplement the health of those who are weak, but generally, everyone will choose to drink with ginseng or ginseng. Stew soup, because its nutrients will be more easily absorbed by people, in fact, it has essences in ginseng, these essences can be taken out by extraction, then what is the effect of pharmaceutical ginseng extract?
White ginseng extract is derived from the dried roots and rhizomes of the ginseng of the Araliaceae family. It is a common supplementary Chinese medicine and a very precious variety in China. Ginseng first appeared in "Shen Nong's Materia Medica" and was listed as the top grade, saying that it "makes up the five internal organs, calms the spirit, fixes the soul, stops the palpitations, eliminates evil spirits, improves the eyesight and puzzles, and the long service lightens the life. Ginseng has the effect of preventing and curing various diseases and nourishing and strengthening the human body. It is used in modern clinics to treat diseases such as weak pulse, cold limbs, shock and heart failure caused by various reasons. The chemical components of ginseng are saponins, sugars, volatile components, organic acids and their esters, proteins, enzymes, sterols and their glycosides, peptides, lignin, nitrogen compounds, flavonoids, vitamins, inorganic elements ingredient. The main active ingredients are ginsenosides and ginseng polysaccharides. This article mainly elaborates on the active ingredient ginsenoside. Ginsenoside is considered to be the main effective substance of ginseng, with a content of about 4%. Ginsenosides belong to triterpenoids, which are glycoside compounds composed of aglycon and sugar. According to the different aglycones, ginsenosides can be divided into 3 types: one is oleanane type pentacyclic triterpenoid saponin R o, and its saponin is oleanolic acid; the other two types are ginsengdiol type saponins Such as R b1, R b2, R c, Rd, F2, R g3, R h2, etc.) and ginseng triol saponins (such as Re, R g1, R g2, Rf, R h1, etc.) It belongs to dammarane type tetracyclic triterpenoid saponins. They account for most of the ginsenosides and are the main active ingredients.
Modern pharmacological studies have shown that ginsenosides have good anti-tumor, anti-inflammatory, anti-oxidation and inhibition of apoptosis and other pharmacological activities. Specifically summarized the following pharmacological activities.
Efficacy of ginseng tract health supplement.
① Influence on endocrine and immune system.
Related studies have shown that intraperitoneal administration of G TS, R b2, R g1, and Rd can reduce the level of plasma IL-6 levels caused by fixed stress. R b2, Rd can significantly reduce norepinephrine and Epinephrine-induced increase in IL-6 content of macrophage cell line, while R g1 significantly reduced the adrenaline-induced increase in IL-6 content of macrophage cell line. That is, ginsenosides have certain activities in regulating immunity and endocrine.
Pharmaceutical Ginseng Extract
② The effect on the circulatory system.
Ginseng can regulate blood pressure, strengthen heart, and protect myocardium in both directions. Ginsenoside R b1 can effectively inhibit ventricular remodeling and protect cardiac function in rats with acute myocardial infarction. Ginsenoside R g1 can significantly increase the number of stem cells in peripheral blood and promote the differentiation of stem cell homing myocardium into cardiomyocyte-like cells, reduce the infarct size, significantly reduce ventricular remodeling, and protect the basic structure of ischemic myocardium.
③, the role of the central nervous system.
Ginseng has a two-way effect of sedation and excitement, which is related to the functional state of the nervous system when it is used. It is also related to the dose size and the different components of ginseng. The mixture of ginsenosides R b and R c has a stabilizing and analgesic effect on the central nervous system of mice, as well as central muscle relaxation, cooling and reducing spontaneous activity. Ginseng decoction has antagonistic effects on many stimulants and can reduce the inhibitory effects of central inhibitors (chloral hydrate, chlorpromazine, etc.). The mixture of ginsenosides R g1, R g2, and R g2 has an excitatory effect on the central nervous system, while a large dose has an inhibitory effect. Studies have shown that ginsenoside R g1 can significantly improve amyloid peptide-induced passive avoidance in mice and can change the activity of AChE, and it is believed that the effect on the cholinergic system may be one of its mechanisms of action on the central nervous system.
④, anti-tumor effect.
Ginsenoside R g2 inhibits the growth of B16 melanoma. The mechanism may be by inhibiting angiogenesis in the tumor and blocking tumor cells from entering the division phase. Ginsenoside R g3 can moderately reverse the resistance of cisplatin-resistant human lung adenocarcinoma cell line A549DDP in a time-dependent manner. Ginsenoside R h2 has an obvious growth inhibitory effect on human larynx carcinoma cell line Hep-2 and can cause G 1 phase cell cycle arrest. Therefore, G 1 cell cycle arrest may be one of the mechanisms of the anti-tumor effect of ginseng monomer saponin R h2. Ginsenoside R h2 can inhibit proliferation and induce differentiation of hepatoma cells SM M C-7721. Ginsenoside R h1 has stronger anti-tumor effects in vivo and in vitro than its precursor R g1.
Ginsenoside has a significant anti-aging effect on the skin of mice, it can significantly improve the skin antioxidant enzyme activity and enhance fibroblast activity. Ginsenosides can increase the activity of antioxidant enzymes in mice, increase the quality of immune organs, and have a good anti-aging effect.